Myocardial scarring after transmyocardial laser revascularization: A potential mechanism of clinical improvement?

Details

Serval ID
serval:BIB_A2BE2FC1A93A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Myocardial scarring after transmyocardial laser revascularization: A potential mechanism of clinical improvement?
Journal
Lasers in Surgery and Medicine
Author(s)
Mueller  X. M., Tevaearai  H. T., Genton  C. Y., von Segesser  L. K.
ISSN
0196-8092
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
25
Number
1
Pages
79-87
Notes
Comparative Study
Journal Article
Abstract
BACKGROUND AND OBJECTIVE: The morphological evolution of transmyocardial laser channels was analyzed in a pig model. MATERIALS AND METHODS: Five channels were created in the lateral wall of the left ventricle of 12 animals, using a Ho:YAG laser. In half of the animals, an additional infarction was induced in the same area. Animals were sacrificed at one-week intervals until week 5 and the critical regions of the left ventricular wall were subjected to microscopic computed morphometrical analysis. RESULTS: There was no clearly patent lumen at any stage. Cross-sectional area of the channels fell from 8.5 +/- 1.2 mm(2) at day 0 to 2.1 +/- 0.1 mm(2) at day 35. From day 7 onward, the channel area was gradually replaced by granulation tissue and the proportion of the channel occupied by granulation scar tissue increased from 37 +/- 2% at day 7 to 100% at day 28. In the subgroup with concomitant infarction, granulation tissue of both channel and infarction became indistinguishable from day 14 onward. CONCLUSIONS: These results suggest strongly that channel patency is not the mechanism of angina relief after transmyocardial laser revascularization with Ho:YAG laser.
Keywords
Animals Cardiac Surgical Procedures Cicatrix/etiology/*pathology Disease Models, Animal Female Heart/radiation effects Laser Therapy/adverse effects/*methods Male Myocardial Infarction/pathology/*surgery Myocardial Revascularization/adverse effects/*methods Myocardium/*pathology Reference Values Swine
Pubmed
Web of science
Create date
14/02/2008 14:17
Last modification date
20/08/2019 15:08
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