Expression des pompes calciques de type SERCA au cours de la différenciation cellulaire et de la tumorigenèse: application à la carcinogenèse colique [Expression of SERCA pumps during cell differentiation and tumorigenesis: application to colonic carcinogenesis].

Détails

ID Serval
serval:BIB_A24D9A7C1121
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Expression des pompes calciques de type SERCA au cours de la différenciation cellulaire et de la tumorigenèse: application à la carcinogenèse colique [Expression of SERCA pumps during cell differentiation and tumorigenesis: application to colonic carcinogenesis].
Périodique
Annales De Pathologie
Auteur(s)
Brouland J.P., Valleur P., Papp B.
ISSN
0242-6498 (Print)
ISSN-L
0242-6498
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
26
Numéro
3
Pages
159-172
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Résumé
Calcium homeostasis of the endoplasmic reticulum (ER) is involved in intracellular signaling pathways and is implicated in major cell functions such as cell growth, differentiation, protein synthesis and apoptosis. The accumulation of calcium in the ER is performed by specific sarco/endoplasmic reticulum calcium transport ATPases (SERCA iso-enzymes). The expression of biochemically distinct SERCA isoforms is cell type dependent and developmentally regulated. This review summarizes pertinent data about the modulation of the expression of SERCA enzymes during the differentiation of normal and tumor cells. These data support the implication of SERCA pumps and especially SERCA3 in the differentiation program of cancer and leukemia cells. During the multi-step process of colon carcinogenesis, the decrease of SERCA3 expression seems to be linked to enhanced APC/ss-catenin/TCF4 signaling and deficient Sp1-like factor-dependent transcription.
Mots-clé
Cell Differentiation, Colonic Neoplasms/genetics, Colonic Neoplasms/pathology, Endoplasmic Reticulum/enzymology, Endoplasmic Reticulum/pathology, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Isoenzymes/genetics, Lymphocyte Activation, Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics
Pubmed
Web of science
Création de la notice
13/10/2015 10:53
Dernière modification de la notice
03/03/2018 20:09
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