Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin

Détails

ID Serval
serval:BIB_A131C29D3D63
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin
Périodique
Obesity Research
Auteur(s)
Marques-Vidal P., Bongard V., Ruidavets J.B., Fauvel J., Hanaire-Broutin H., Perret B., Ferrières J.
ISSN
1071-7323 (Print)
ISSN-L
1071-7323
Statut éditorial
Publié
Date de publication
2003
Volume
11
Numéro
10
Pages
1200-1206
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVE: To assess the interaction between apolipoprotein (apo) E polymorphism, alcohol consumption, and BMI on insulin, lipid, and lipoprotein levels in men.
RESEARCH METHODS AND PROCEDURES: Cross-sectional study of 266 healthy men without hypolipidemic or antidiabetic drug treatment. BMI, apo E polymorphisms, insulin, and lipid and lipoprotein levels were assessed. Alcohol consumption was assessed by questionnaire. epsilon2/epsilon4 carriers were excluded from the analysis.
RESULTS: On bivariate analysis, epsilon2 carriers had lower levels of total and low-density lipoprotein cholesterol and higher levels of apo E and lipoparticle B:E than epsilon3 carriers, the opposite being found for epsilon4 carriers compared with epsilon3 carriers; epsilon4 carriers also had significantly higher insulin levels. On multivariate analysis, significant interactions (p < 0.04) between apo E alleles and increased BMI were found for total and low-density lipoprotein cholesterol and insulin levels, the increase in those parameters with BMI being stronger among epsilon4 carriers than among epsilon3 or epsilon2 carriers. Significant interactions (p < 0.02) between apo E alleles and alcohol consumption were also found for apo B levels, which increased in epsilon2 carriers but remained relatively stable in epsilon3 and tended to decrease in epsilon4 carriers.
DISCUSSION: These data suggest that effects of apo E alleles on lipids and insulin levels are partly dependent on environmental variables such as BMI and alcohol intake. These findings highlight the importance of gene x environment interactions on the deleterious effect of obesity on cardiovascular risk factors.
Mots-clé
Alcohol Drinking/blood, Apolipoproteins E/blood, Apolipoproteins E/genetics, Cholesterol/blood, DNA/chemistry, DNA/genetics, Insulin/blood, Obesity/blood, Obesity/genetics, Polymorphism, Genetic/physiology, Smoking/blood, Triglycerides/blood
Pubmed
Web of science
Création de la notice
01/12/2016 16:01
Dernière modification de la notice
03/03/2018 20:07
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