Prevalence of normal TSH value among patients with autonomously functioning thyroid nodule.

Details

Serval ID
serval:BIB_A1090E595B57
Type
Article: article from journal or magazin.
Collection
Publications
Title
Prevalence of normal TSH value among patients with autonomously functioning thyroid nodule.
Journal
European journal of clinical investigation
Author(s)
Treglia G., Trimboli P., Verburg F.A., Luster M., Giovanella L.
ISSN
1365-2362 (Electronic)
ISSN-L
0014-2972
Publication state
Published
Issued date
07/2015
Peer-reviewed
Oui
Volume
45
Number
7
Pages
739-744
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Abstract
International guidelines significantly diverge on the effectiveness of thyroid scintigraphy (TS) in the initial work-up of thyroid nodules. In particular, the role of TS to detect or exclude the presence of autonomously functioning thyroid nodules (AFTN) in patients with normal serum thyrotropin (TSH) is still a matter to debate. Here, we aimed to review the literature on the prevalence of normal TSH value among patients with AFTN and meta-analyse data of the retrieved eligible papers.
A comprehensive literature search of studies published from January 2000 to December 2014 on AFTN detected by TS was performed. Records reporting serum TSH values in AFTN were selected. Pooled prevalence of AFTN with normal TSH values was calculated on a per-patient analysis including 95% confidence intervals (95% CI).
Eight records including 2761 AFTN were selected for the meta-analysis. Pooled prevalence of AFTN with normal TSH detected by TS was 50% (95% CI: 32-68%). Selection bias in the included studies and heterogeneity among studies were potential limitations of the meta-analysis.
Present meta-analysis shows that about one in two patients with AFTN demonstrated by TS has a TSH value within normal references. As a consequence, TSH measurement may not be considered as effective as a single tool to detect or exclude AFTN, and TS remains mandatory.

Keywords
Epidemiologic Methods, Humans, Radionuclide Imaging, Thyroid Nodule/blood, Thyroid Nodule/diagnostic imaging, Thyroid Nodule/physiopathology, Thyrotropin/blood, Autonomously functioning thyroid nodule, meta-analysis, nodular goitre, scintigraphy, thyroid, thyroid-stimulating hormone
Pubmed
Web of science
Open Access
Yes
Create date
20/08/2017 17:02
Last modification date
20/08/2019 15:07
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