The analgesic efficacy and safety of neuraxial magnesium sulphate: a quantitative review.

Détails

ID Serval
serval:BIB_A083775D91E6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The analgesic efficacy and safety of neuraxial magnesium sulphate: a quantitative review.
Périodique
Anaesthesia
Auteur(s)
Albrecht E., Kirkham K.R., Liu S.S., Brull R.
ISSN
1365-2044 (Electronic)
ISSN-L
0003-2409
Statut éditorial
Publié
Date de publication
02/2013
Volume
68
Numéro
2
Pages
190-202
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
quantitative systematic review
Résumé
Eighteen published trials have examined the use of neuraxial magnesium as a peri-operative adjunctive analgesic since 2002, with encouraging results. However, concurrent animal studies have reported clinical and histological evidence of neurological complications with similar weight-adjusted doses. The objectives of this quantitative systematic review were to assess both the analgesic efficacy and the safety of neuraxial magnesium. Eighteen trials comparing magnesium with placebo were identified. The time to first analgesic request increased by 11.1% after intrathecal magnesium administration (mean difference: 39.6 min; 95% CI 16.3-63.0 min; p = 0.0009), and by 72.2% after epidural administration (mean difference: 109.5 min; 95% CI 19.6-199.3 min; p = 0.02) with doses of between 50 and 100 mg. Four trials monitored for neurological complications: of the 140 patients included, only a 4-day persistent headache was recorded. Despite promising peri-operative analgesic effect, the risk of neurological complications resulting from neuraxial magnesium has not yet been adequately defined.
Mots-clé
Analgesics/adverse effects, Analgesics/therapeutic use, Headache/chemically induced, Humans, Magnesium Sulfate/adverse effects, Magnesium Sulfate/therapeutic use, Pain, Postoperative/drug therapy, Postoperative Complications/chemically induced, Treatment Outcome
Pubmed
Web of science
Création de la notice
10/12/2013 16:52
Dernière modification de la notice
20/08/2019 16:06
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