Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma.
Journal of Clinical Endocrinology and Metabolism
Publication types: Case Reports ; Journal Article
The potential role of angiotensin-II in mediating catecholamine and neuropeptide-Y release in a human pheochromocytoma has been investigated. Angiotensin-II type I receptors are transcribed and translated into functional proteins in a surgically removed pheochromocytoma. Primary cell culture of the tumor has been studied in a perfused system. Angiotensin-II increased the release of norepinephrine and neuropeptide-Y by the pheochromocytes. Activation of the angiotensin-II type I receptors by angiotensin-II was associated with a rise in cytosolic free calcium. The renin-angiotensin system may, therefore, contribute to the secretion of catecholamines and NPY occurring in patients with pheochromocytoma and when stimulated trigger hypertensive crisis.
Adrenal Gland Neoplasms, Adult, Angiotensin II, Calcium, Gene Expression, Humans, Male, Neuropeptide Y, Norepinephrine, Perfusion, Pheochromocytoma, Receptors, Angiotensin, Renin-Angiotensin System, Tumor Cells, Cultured
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