Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma.

Détails

ID Serval
serval:BIB_9EFF36B0225E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma.
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Grouzmann E., Werffeli-George P., Fathi M., Burnier M., Waeber B., Waeber G.
ISSN
0021-972X
Statut éditorial
Publié
Date de publication
1994
Peer-reviewed
Oui
Volume
79
Numéro
6
Pages
1852-1856
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
The potential role of angiotensin-II in mediating catecholamine and neuropeptide-Y release in a human pheochromocytoma has been investigated. Angiotensin-II type I receptors are transcribed and translated into functional proteins in a surgically removed pheochromocytoma. Primary cell culture of the tumor has been studied in a perfused system. Angiotensin-II increased the release of norepinephrine and neuropeptide-Y by the pheochromocytes. Activation of the angiotensin-II type I receptors by angiotensin-II was associated with a rise in cytosolic free calcium. The renin-angiotensin system may, therefore, contribute to the secretion of catecholamines and NPY occurring in patients with pheochromocytoma and when stimulated trigger hypertensive crisis.
Mots-clé
Adrenal Gland Neoplasms, Adult, Angiotensin II, Calcium, Gene Expression, Humans, Male, Neuropeptide Y, Norepinephrine, Perfusion, Pheochromocytoma, Receptors, Angiotensin, Renin-Angiotensin System, Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
17/11/2008 9:57
Dernière modification de la notice
03/03/2018 20:01
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