Survival according to the site of bronchial microscopic residual disease after lung resection for non-small cell lung cancer.

Details

Serval ID
serval:BIB_9EFC71E382EA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Survival according to the site of bronchial microscopic residual disease after lung resection for non-small cell lung cancer.
Journal
Journal of Thoracic and Cardiovascular Surgery
Author(s)
Collaud S., Bongiovanni M., Pache J.C., Fioretta G., Robert J.H.
ISSN
1097-685X (Electronic)
ISSN-L
0022-5223
Publication state
Published
Issued date
2009
Volume
137
Number
3
Pages
622-626
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
OBJECTIVE: We performed a retrospective study evaluating the effect on survival of different sites of microscopic residual disease at the bronchial resection margin after surgical intervention for non-small cell lung cancer.
METHODS: Survival of patients with different sites of residual disease was compared with survival of patients with curative resections, taking the pathologic TNM stage of the tumor into consideration.
RESULTS: There was a trend for patients with stage I and II non-small cell lung cancer with residual disease limited to the epithelium and with peribronchial invasion to behave like patients with complete resections (61% and 41% five-year survival for stage I and II disease, respectively). This contrasts with patients with submucosal invasion and lymphatic infiltration, among whom there were no survivors at 5 years. There was no difference in survival between curative resections and residual disease of any type when the tumor was stage III or IV.
CONCLUSIONS: In patients with stage I and II disease, when residual disease consists of submucosal invasion or lymphatic infiltration, specific and aggressive treatments to clear residual margins might be contemplated because of their possible adverse effect on survival. This contrasts with patients with stage III and IV disease, in whom survival is more related to the stage of the primary tumor than to residual disease.
Keywords
Adult, Aged, Bronchi/pathology, Carcinoma, Non-Small-Cell Lung/mortality, Carcinoma, Non-Small-Cell Lung/pathology, Female, Humans, Lung Neoplasms/mortality, Lung Neoplasms/pathology, Male, Middle Aged, Neoplasm, Residual, Pneumonectomy, Retrospective Studies, Survival Rate
Pubmed
Web of science
Open Access
Yes
Create date
05/02/2015 11:04
Last modification date
20/08/2019 15:05
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