The functional costs and benefits of dietary restriction in Drosophila.

Détails

ID Serval
serval:BIB_9EE21DABBFA1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The functional costs and benefits of dietary restriction in Drosophila.
Périodique
Aging Cell
Auteur(s)
Burger J.M., Hwangbo D.S., Corby-Harris V., Promislow D.E.
ISSN
1474-9718
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
6
Numéro
1
Pages
63-71
Langue
anglais
Résumé
Dietary restriction (DR) extends lifespan in an impressively wide array of species spanning three eukaryotic kingdoms. In sharp contrast, relatively little is known about the effects of DR on functional senescence, with most of the work having been done on mice and rats. Here we used Drosophila melanogaster to test the assumption that lifespan extension through DR slows down age-related functional deterioration. Adult virgin females were kept on one of three diets, with sucrose and yeast concentrations ranging from 7% to 11% to 16% (w/v). Besides age-specific survival and fecundity, we measured starvation resistance, oxidative stress resistance, immunity, and cold-stress resilience at ages 1, 3, 5, and 7 weeks. We confirmed that DR extends lifespan: median lifespans ranged from 38 days (16% diet) to 46 days (11% diet) to 54 days (7% diet). We also confirmed that DR reduces fecundity, although the shortest-lived flies only had the highest fecundity when males were infrequently available. The most striking result was that DR initially increased starvation resistance, but strongly decreased starvation resistance later in life. Generally, the effects of DR varied across traits and were age dependent. We conclude that DR does not universally slow down functional deterioration in Drosophila. The effects of DR on physiological function might not be as evolutionarily conserved as its effect on lifespan. Given the age-specific effects of DR on functional state, imposing DR late in life might not provide the same functional benefits as when applied at early ages.
Mots-clé
Aging/physiology, Animals, Caloric Restriction, Cold Temperature/adverse effects, Drosophila melanogaster/physiology, Female, Fertility/physiology, Food Deprivation/physiology, Immune System/physiology, Immunity, Innate/physiology, Longevity/physiology, Male, Oxidative Stress/physiology, Starvation/metabolism, Stress, Physiological/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 10:42
Dernière modification de la notice
20/08/2019 15:05
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