Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.

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Serval ID
serval:BIB_9E8335A1E780
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning.
Journal
Nature Communications
Author(s)
Jacovetti C., Matkovich S.J., Rodriguez-Trejo A., Guay C., Regazzi R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
6
Pages
8084
Language
english
Abstract
Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we show that β-cell maturation is associated with changes in microRNA expression induced by the nutritional transition that occurs at weaning. When mimicked in newborn islet cells, modifications in the level of specific microRNAs result in a switch in the expression of metabolic enzymes and cause the acquisition of glucose-induced insulin release. Our data suggest microRNAs have a central role in postnatal β-cell maturation and in the determination of adult functional β-cell mass. A better understanding of the events governing β-cell maturation may help understand why some individuals are predisposed to developing diabetes and could lead to new strategies for the treatment of this common metabolic disease.
Keywords
Animals, Cell Differentiation/genetics, Cells, Cultured, Diabetes Mellitus, Type 2/genetics, Flow Cytometry, Gene Expression Regulation, Developmental, Immunohistochemistry, Insulin/secretion, Insulin-Secreting Cells/metabolism, Insulin-Secreting Cells/secretion, Islets of Langerhans/metabolism, Islets of Langerhans/secretion, MicroRNAs/genetics, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Weaning
Pubmed
Web of science
Open Access
Yes
Create date
10/09/2015 8:00
Last modification date
20/08/2019 15:04
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