Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.

Details

Serval ID
serval:BIB_9DB3A0983F4B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.
Journal
Journal of Neuropathology and Experimental Neurology
Author(s)
Anneser J.M., Chahli C., Ince P.G., Borasio G.D., Shaw P.J.
ISSN
0022-3069 (Print)
ISSN-L
0022-3069
Publication state
Published
Issued date
2004
Volume
63
Number
8
Pages
831-840
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Accumulating evidence indicates that alterations in glial activation and disturbances in glial glutamate metabolism may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). Metabotropic glutamate receptors (mGluRs) are involved in glutamate homeostasis as well as in glial proliferation. Using in situ hybridization and immunohistochemistry we found a strong upregulation of group I and group II mGluR mRNA and protein in ALS spinal cord as compared to controls (mGluR5 > mGluR1 > mGluR2/3). In vitro, the mGluR group I agonist 3,5-dihydroxyphenylglycine induced proliferation in chick spinal cord astroglial cultures. Moreover, addition of cerebrospinal fluid (CSF) from ALS patients resulted in significantly higher proliferation rates than control CSF. In both cases, the effect could be blocked by addition of the mGluR group I antagonist 1-aminoindan-1,5-dicarboxylic acid. Taken together, our data suggest that stimulation of glial mGluRs through mediators present in the CSF may contribute to glial proliferation and astrogliosis in ALS.
Keywords
Aged, Amyotrophic Lateral Sclerosis/metabolism, Amyotrophic Lateral Sclerosis/pathology, Animals, Brain/drug effects, Brain/metabolism, Cell Division/drug effects, Cell Division/physiology, Chick Embryo, Excitatory Amino Acid Agonists/pharmacology, Female, Gene Expression Regulation/drug effects, Gene Expression Regulation/physiology, Humans, Male, Middle Aged, Neuroglia/drug effects, Neuroglia/metabolism, Receptors, Metabotropic Glutamate/agonists, Receptors, Metabotropic Glutamate/biosynthesis
Pubmed
Web of science
Create date
13/01/2014 17:27
Last modification date
20/08/2019 15:04
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