Putative adverse outcome pathways relevant to neurotoxicity.

Details

Serval ID
serval:BIB_9D982FBE4F81
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Putative adverse outcome pathways relevant to neurotoxicity.
Journal
Critical Reviews in Toxicology
Author(s)
Bal-Price A., Crofton K.M., Sachana M., Shafer T.J., Behl M., Forsby A., Hargreaves A., Landesmann B., Lein P.J., Louisse J., Monnet-Tschudi F., Paini A., Rolaki A., Schrattenholz A., Suñol C., van Thriel C., Whelan M., Fritsche E.
ISSN
1547-6898 (Electronic)
ISSN-L
1040-8444
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
45
Number
1
Pages
83-91
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological target(s), followed by a sequential series of KEs, which are cellular, anatomical, and/or functional changes in biological processes, that ultimately result in an AO manifest in individual organisms and populations. It has been developed as a tool for a knowledge-based safety assessment that relies on understanding mechanisms of toxicity, rather than simply observing its adverse outcome. A large number of cellular and molecular processes are known to be crucial to proper development and function of the central (CNS) and peripheral nervous systems (PNS). However, there are relatively few examples of well-documented pathways that include causally linked MIEs and KEs that result in adverse outcomes in the CNS or PNS. As a first step in applying the AOP framework to adverse health outcomes associated with exposure to exogenous neurotoxic substances, the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) organized a workshop (March 2013, Ispra, Italy) to identify potential AOPs relevant to neurotoxic and developmental neurotoxic outcomes. Although the AOPs outlined during the workshop are not fully described, they could serve as a basis for further, more detailed AOP development and evaluation that could be useful to support human health risk assessment in a variety of ways.
Pubmed
Web of science
Create date
21/02/2015 14:00
Last modification date
20/08/2019 15:03
Usage data