Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The role of dendritic cell precursors in tumour vasculogenesis.
British Journal of Cancer
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; ReviewPublication Status: ppublish
In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into functional blood vessels or act as antigen-presenting cells. The identification of dendritic cell precursors as bipotent cells has important implications for the physiopathology and therapy of tumours. VLCs emerge as a novel therapeutic target against tumour vascularisation.
Antigens, CD11c, Cell Differentiation, Dendritic Cells/physiology, Humans, Immunotherapy, Leukocytes, Neoplasms/blood supply, Neoplasms/drug therapy, Neovascularization, Pathologic, Vascular Endothelial Growth Factor A/pharmacology
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