Article: article from journal or magazin.
Pharmacodynamic and humoral effects of single intravenous doses of captopril in normal subjects.
Clinical and experimental hypertension. Part A, Theory and practice
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial - Publication Status: ppublish
The blood pressure, heart rate and humoral responses to single intravenous doses of the angiotensin converting enzyme inhibitor captopril were evaluated in 5 volunteers on a free salt intake. Each subject was given at one-week intervals a 1, 5 and 25 mg intravenous dose of captopril as well as the vehicle of captopril. The study was conducted in a single-blind fashion and the order of treatment phases was randomized. Captopril was found to inhibit the renin-angiotensin system in a dose-dependent fashion. A fall in circulating angiotensin II was observed with doses of 1 and 5 mg. Plasma angiotensin II was not detectable 15 min after the 25 mg dose. Acute inhibition of angiotensin converting enzyme with intravenous captopril had no effect on blood pressure and heart rate.
Adult, Angiotensin II, Captopril, Hemodynamics, Humans, Injections, Intravenous, Male
Web of science
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