Article: article from journal or magazin.
Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla.
Magnetic Resonance in Medicine
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Broadband proton decoupling of the entire 13C spectrum was possible within power absorption guidelines and resulted in the detection of narrow (as low as 2-3 Hz), natural abundance signals from metabolites such as myo-inositol, glutamate, N-acetyl-aspartate, and glutamine from 72 cm3 volumes in the human brain. To overcome the chemical shift displacement error, three-dimensional localization on the 1H z magnetization was combined with polarization transfer. Efficiency of the heteronuclear localization method was demonstrated by the elimination of all scalp lipid resonances. A signal-to-noise ratio of 5:1 for 0.07 mM [13C] was achieved in 12 min, which is approximately a fivefold improvement over the sensitivity reported at 2.1 Tesla.
Aspartic Acid/analogs & derivatives, Aspartic Acid/analysis, Brain Chemistry, Glutamic Acid/analysis, Glutamine/analysis, Humans, Inositol/analysis, Magnetic Resonance Spectroscopy/methods
Web of science
Last modification date