Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla.

Details

Serval ID
serval:BIB_9B7F9D6BE954
Type
Article: article from journal or magazin.
Collection
Publications
Title
Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla.
Journal
Magnetic Resonance in Medicine
Author(s)
Gruetter R., Adriany G., Merkle H., Andersen P.M.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Publication state
Published
Issued date
1996
Volume
36
Number
5
Pages
659-664
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
Broadband proton decoupling of the entire 13C spectrum was possible within power absorption guidelines and resulted in the detection of narrow (as low as 2-3 Hz), natural abundance signals from metabolites such as myo-inositol, glutamate, N-acetyl-aspartate, and glutamine from 72 cm3 volumes in the human brain. To overcome the chemical shift displacement error, three-dimensional localization on the 1H z magnetization was combined with polarization transfer. Efficiency of the heteronuclear localization method was demonstrated by the elimination of all scalp lipid resonances. A signal-to-noise ratio of 5:1 for 0.07 mM [13C] was achieved in 12 min, which is approximately a fivefold improvement over the sensitivity reported at 2.1 Tesla.
Keywords
Aspartic Acid/analogs & derivatives, Aspartic Acid/analysis, Brain Chemistry, Glutamic Acid/analysis, Glutamine/analysis, Humans, Inositol/analysis, Magnetic Resonance Spectroscopy/methods
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 15:02
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