Amino acid modulation of lifespan and reproduction in Drosophila.

Détails

ID Serval
serval:BIB_9ACC7577CB61
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Amino acid modulation of lifespan and reproduction in Drosophila.
Périodique
Current opinion in insect science
Auteur(s)
Hoedjes K.M., Rodrigues M.A., Flatt T.
ISSN
2214-5753 (Electronic)
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
23
Pages
118-122
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. Remarkably, AA manipulation can uncouple the commonly observed trade-off between these traits. This finding seems to challenge the idea that this trade-off is due to competitive resource allocation, but here we argue that this view might be too simplistic. We also discuss the mechanisms of the AA response, mediated by the IIS/TOR and GCN2 pathways. Elucidating how these pathways respond to specific AA will likely yield important insights into how AA modulate the reproduction-lifespan relationship. The Drosophila model offers powerful genetic tools, combined with options for precise diet manipulation, to address these fundamental questions.
Mots-clé
Amino Acids, Animals, Diet, Drosophila/genetics, Drosophila/physiology, Female, Longevity/physiology, Male, Reproduction/physiology, Signal Transduction/physiology
Pubmed
Web of science
Création de la notice
05/01/2018 11:01
Dernière modification de la notice
20/08/2019 16:01
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