Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia.

Details

Serval ID
serval:BIB_9886A5916F31
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia.
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Barter P., McPherson Y.R., Song K., Kesäniemi Y.A., Mahley R., Waeber G., Bersot T., Mooser V., Waterworth D., Grundy S.M.
ISSN
0021-972X
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
92
Number
6
Pages
2041-2045
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
CONTEXT: The worldwide epidemic of overweight and obesity is setting the scene for a new wave of premature cardiovascular disease. OBJECTIVE: The objective of this study was to define relationships between dyslipidemia and other metabolic abnormalities in overweight subjects. DESIGN: This study included comparison of overweight subjects with and without dyslipidemia. SETTING: The setting was an institutional practice. PATIENTS: Dyslipidemic subjects (n = 715) had plasma triglyceride greater than or equal to the 75th percentile in combination with high-density lipoprotein cholesterol (HDL-C) less than or equal to the 25th percentile. Unrelated, normolipidemic controls (n = 1073) had HDL-C higher than the median and triglyceride lower than the median. It was a requirement for the control subjects to have a body mass index (BMI) greater than 25 kg/m(2). MAIN OUTCOME MEASURES: The main outcome measures included BMI, inflammatory markers, adipokines, blood pressure, and fasting plasma glucose and insulin. RESULTS: The mean BMI in the subjects and controls was 28.7 and 28.2 kg/m(2), respectively. Subjects had higher levels of plasma high-sensitivity C-reactive protein (3.0 vs. 2.0 mg/liter; P < 0.001), lower levels of adiponectin (4.7 vs. 6.6 mg/liter; P < 0.001), and, after adjustment for age, BMI, gender, smoking, statin, and beta-blocker use, higher systolic (P = 0.001) and diastolic (P = 0.05) blood pressures. Fasting plasma glucose, insulin, and homeostasis model of assessment-insulin resistance were all significantly higher in subjects than controls (P < 0.0001). CONCLUSIONS: Identification of people solely on the basis of an elevated plasma triglyceride and a low HDL-C uncovers an overweight group of people who have a generalized metabolic disorder. In contrast, overweight people with normal plasma lipids have normal glucose and insulin metabolism, low levels of inflammatory markers, and normal blood pressure. Such people may thus be at relatively low risk of developing diabetes and cardiovascular disease despite being overweight.
Keywords
Adult, Biological Markers, Blood Glucose, Blood Pressure, Body Mass Index, Cholesterol, HDL, Dyslipidemias, Female, Humans, Insulin, Male, Middle Aged, Obesity, Risk Factors, Triglycerides
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:10
Last modification date
20/08/2019 15:00
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