Syndrome métabolique, une maladie mitochondriale? [Metabolic syndrome, a mitochondrial disease?]

Details

Serval ID
serval:BIB_9804C4FCBBC1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Syndrome métabolique, une maladie mitochondriale? [Metabolic syndrome, a mitochondrial disease?]
Journal
Revue Médicale Suisse
Author(s)
Gastaldi G., Giacobino J. P., Ruiz J.
ISSN
1660-9379
Publication state
Published
Issued date
2008
Volume
4
Number
160
Pages
1387-1391
Language
french
Abstract
Le syndrome métabolique (SM) associe dyslipidémie, hypertension, intolérance au glucose, état pro-inflammatoire/prothrombotique et surpoids, dont nous vous présentons une hypothèse physiopathologique émergente. Des recherches récentes ont montré que des dysfonctions mitochondriales induisent l'accumulation intracellulaire d'acylCoA et de diacylglycérol, inactivant la signalisation de l'insuline par un effet direct sur les transporteurs du glucose insulino-dépendants. Un défaut de la phosphorylation oxydative conduirait à l'insulino-résistance. Des atteintes de la fonction mitochondriale sont présentes dans le muscle, le foie, le pancréas et les vaisseaux sanguins et contribuent aux manifestations cliniques. Ces observations des atteintes mitochondriales nous montrent un lien entre la clinique et la physiopathologie du SM.
The metabolic syndrome is a cluster of metabolic risk factors including: atherogenic dyslipidemia, elevated blood pressure, high plasma glucose and a prothrombotic and proinflammatory state, frequently associated to overweight. Impaired cell metabolism has been suggested as a relevant pathophysiological process. Indeed, the accumulation of intracellular fatty acylCoA and diacylglycerol, which then activate critical signal transduction pathways that ultimatly lead to suppression of insulin signalisation. Therefore a defect in mitochondrial function may be responsible for insulin resistance. Moreover, mitochondrial dysfunction has been found to take place in organs such as skeletal muscle, liver, pancreas and smoth vascular cells suggesting that mitochondrial defect could play a critical role in the occurence of cardiovascular diseases.
Keywords
blood , Cardiovascular Diseases , genetics , Glucose , Humans , Insulin , Metabolic Syndrome X , metabolism , Mitochondria , Overweight , Oxidative Phosphorylation , physiology , physiopathology , Risk , Risk Factors , Signal Transduction
Pubmed
Create date
29/01/2009 22:14
Last modification date
20/08/2019 14:59
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