Thyroid hormone use, hyperthyroidism and mortality in older women

Details

Serval ID
serval:BIB_96190FFCD6F6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thyroid hormone use, hyperthyroidism and mortality in older women
Journal
American Journal of Medicine
Author(s)
Bauer  D. C., Rodondi  N., Stone  K. L., Hillier  T. A.
ISSN
1555-7162 (Electronic)
Publication state
Published
Issued date
04/2007
Peer-reviewed
Oui
Volume
120
Number
4
Pages
343-9
Notes
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
PURPOSE: Thyroid dysfunction is common, particularly among older women. The safety of thyroid hormone use and long-term prognosis of hyperthyroidism remain controversial. We performed a prospective cohort study to examine the relationship among thyroid hormone use, previous hyperthyroidism, abnormal thyroid function, and mortality. METHODS: We studied 9449 community-dwelling white women aged > or =65 years followed for 12 years. For analyses of thyroid function, we performed a nested case-cohort in 487 women using a third-generation thyroid-stimulating hormone assay. Causes of death were adjudicated based on death certificates and hospital records. RESULTS: Twelve percent of the 9449 women took thyroid hormone at baseline, and the mean duration of thyroid hormone use was 15.8 years; 9.4% of participants reported a history of hyperthyroidism. During 12 years of follow-up, 3159 women died (33%). In multivariate analysis, mortality among users of thyroid hormone was similar to that observed for nonusers (relative hazard [RH] 1.11, 95% confidence interval [CI], 0.98-1.24, P=.09). Previous hyperthyroidism was associated with a higher risk of all-cause mortality (RH 1.20, 95% CI, 1.06-1.36), particularly cardiovascular mortality (RH 1.46, 95% CI, 1.20-1.77). Low (< or /=0.5 mU/L) or high (>5 mU/L) thyroid-stimulating hormone levels were not associated with excess total or cause-specific mortality, but the power to detect these relationships was limited. CONCLUSIONS: Among older women, thyroid hormone use is not associated significantly with excess mortality, but previous hyperthyroidism may be associated with a small increase in all-cause and cardiovascular mortality. Additional long-term studies of hyperthyroidism and its treatment should further explore these findings.
Keywords
Age Distribution Aged Body Weight Cardiovascular Diseases/mortality Case-Control Studies Cause of Death Cohort Studies Comorbidity Female Follow-Up Studies Health Status Humans Hyperthyroidism/*drug therapy/metabolism/*mortality Life Style Multivariate Analysis Neoplasms/mortality Prospective Studies Risk Factors Thyroid Hormones/*therapeutic use Thyrotropin/metabolism United States/epidemiology
Pubmed
Web of science
Create date
28/01/2008 12:01
Last modification date
20/08/2019 14:58
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