A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.

Détails

Ressource 1Télécharger: BIB_95A9A36DBF17.P001.pdf (514.29 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_95A9A36DBF17
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
Périodique
Plos One
Auteur(s)
Hohm Tim, Zitzler Eckart, Simon Ruediger
ISSN
1932-6203[electronic], 1932-6203[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
5
Numéro
2
Pages
9189
Langue
anglais
Résumé
Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life. Meristems are small groups of cells that provide the microenvironment that allows stem cells to prosper. Homeostasis of a stem cell domain within a growing meristem is achieved by signalling between stem cells and surrounding cells. We have here simulated the origin and maintenance of a defined stem cell domain at the tip of Arabidopsis shoot meristems, based on the assumption that meristems are self-organizing systems. The model comprises two coupled feedback regulated genetic systems that control stem cell behaviour. Using a minimal set of spatial parameters, the mathematical model allows to predict the generation, shape and size of the stem cell domain, and the underlying organizing centre. We use the model to explore the parameter space that allows stem cell maintenance, and to simulate the consequences of mutations, gene misexpression and cell ablations.
Mots-clé
Shoot Meristem, Gene Encodes, Wuschel, Fate, Expression, Kinase, Loop
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/03/2010 17:40
Dernière modification de la notice
08/05/2019 22:17
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