Article: article from journal or magazin.
CD62L(high) Treg cells with superior immunosuppressive properties accumulate within the CNS during remissions of EAE.
Brain, Behavior, and Immunity
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The role of regulatory T cell populations within the CNS in the regulation of CNS-autoimmunity is controversial. We show that during recovery from relapsing remitting experimental autoimmune encephalomyelitis, regulatory T cells accumulate within the CNS that express high levels of CD62L. These CD62L(high) Treg cells express increased amounts of CTLA-4, ICOS and TGF-β and are more potent than CD62L(low) Treg cells in suppressing proliferation and inducing apoptosis in effector T cells. CD62L(high) Treg cells thus represent a population of Treg cells that display superior immunosuppressive properties and accumulate in the CNS during recovery from CNS-autoimmunity.
Web of science
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