Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus.

Détails

ID Serval
serval:BIB_942D078842B4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus.
Périodique
Journal of Immunology
Auteur(s)
Benedict C.A., Butrovich K.D., Lurain N.S., Corbeil J., Rooney I., Schneider P., Tschopp J., Ware C.F.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
1999
Volume
162
Numéro
12
Pages
6967-6970
Langue
anglais
Résumé
The UL144 open reading frame found in clinical isolates of human CMV (HCMV) encodes a structural homologue of the herpesvirus entry mediator, a member of the TNFR superfamily. UL144 is a type I transmembrane glycoprotein that is expressed early after infection of fibroblasts; however, it is retained intracellularly. A YXXZ motif in the highly conserved cytoplasmic tail contributes to UL144 subcellular distribution. The finding that no known ligand of the TNF family binds UL144 suggests that its mechanism of action is distinct from other known viral immune evasion genes. Specific Abs to UL144 can be detected in the serum of a subset of HCMV seropositive individuals infected with HIV. This work establishes a novel molecular link between the TNF superfamily and herpesvirus that may contribute to the ability of HCMV to escape immune clearance.
Mots-clé
Amino Acid Sequence, Antibodies, Viral/blood, Cell Line, Cytomegalovirus/immunology, Cytomegalovirus/pathogenicity, Cytomegalovirus Infections/blood, Cytomegalovirus Infections/immunology, Humans, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/chemistry, Molecular Sequence Data, Receptors, Tumor Necrosis Factor/biosynthesis, Receptors, Tumor Necrosis Factor/chemistry, Receptors, Tumor Necrosis Factor, Member 14, Receptors, Virus/chemistry, Sequence Homology, Amino Acid, Simplexvirus/immunology, Viral Proteins/biosynthesis, Viral Proteins/chemistry, Virulence/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
03/03/2018 19:36
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