Efficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors

Détails

ID Serval
serval:BIB_93A1C347FBDC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Efficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors
Périodique
Cancer Research
Auteur(s)
Chapatte  L., Colombetti  S., Cerottini  J. C., Levy  F.
ISSN
0008-5472 (Print)
Statut éditorial
Publié
Date de publication
01/2006
Volume
66
Numéro
2
Pages
1155-60
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 15
Résumé
The success of active cancer immunotherapy entails a robust induction of tumor-reactive effector and memory CD8+ T cells. We compared the in vivo immunogenicity of the melanoma-associated antigen Melan-A(26-35) encoded by third-generation recombinant lentivector (rec. lv) or as peptide admixed with a strong adjuvant. Ex vivo analyses of immunized HLA-A2/H-2K(b) mice showed that rec. lv triggered a stronger anti-Melan-A CD8+ T -cell response than peptide vaccine. Importantly, the majority of anti-Melan-A T cells elicited by rec. lv expressed the memory marker CD127 at the peak of the primary response. In those mice, memory T cells were detectable several months after priming and could be activated by recall peptide vaccination. These results show that immunization with rec. lv induces not only a strong antigen-specific CD8+ T -cell response but also a long-lasting T-cell memory against a bona fide tumor-associated antigen.
Mots-clé
Animals Antibody Formation Antigens, Neoplasm/immunology CD8-Positive T-Lymphocytes/*immunology Cancer Vaccines/*immunology Genetic Vectors HLA-A2 Antigen/genetics Immunologic Memory/*immunology Lentivirus/genetics Melanoma/immunology Mice Mice, Transgenic Neoplasm Proteins/immunology Peptide Fragments Skin Neoplasms/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:17
Dernière modification de la notice
08/05/2019 22:10
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