Antibody heterogeneity and specificity in myasthenia gravis

Détails

ID Serval
serval:BIB_9326A9D84832
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antibody heterogeneity and specificity in myasthenia gravis
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Vincent  A., Whiting  P. J., Schluep  M., Heidenreich  F., Lang  B., Roberts  A., Willcox  N., Newsom-Davis  J.
ISSN
0077-8923 (Print)
Statut éditorial
Publié
Date de publication
1987
Volume
505
Pages
106-20
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Anti-AChR is heterogeneous within individuals and between individuals. Anti-AChR idiotypes are not shared to any large extent. Ten monoclonal antibodies raised against human AChR: (a) bind to five partially overlapping regions; (b) are not idiotypically identical even within a region; (c) do not all bind to the main immunogenic region; (d) four distinguish between normal and denervated human AChR; (e) can be used to define the antigenic determinants in MG. Antigenic specificities vary in different clinical groups. Antigenic specificities can change during the course of the disease, but some remain relatively constant. Thymus cultures make antibodies with the same specificity as those present in the serum of the individual. All monoclonal antibodies bind to myoid cells of normal and MG thymus. We find no convincing evidence of naturally occurring antiidiotype antibodies in MG sera.
Mots-clé
Antibodies, Monoclonal/immunology Antibody Specificity Autoantibodies/classification/*immunology Autoimmune Diseases/*immunology Epitopes/immunology Humans Immunoglobulin Idiotypes/immunology Myasthenia Gravis/*immunology/pathology Receptors, Nicotinic/*immunology Thymus Gland/immunology/pathology
Pubmed
Web of science
Création de la notice
25/01/2008 13:46
Dernière modification de la notice
03/03/2018 19:34
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