A fly view on the roles and mechanisms of the m<sup>6</sup>A mRNA modification and its players.

Détails

ID Serval
serval:BIB_931A0BE4FA8B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
A fly view on the roles and mechanisms of the m<sup>6</sup>A mRNA modification and its players.
Périodique
RNA biology
Auteur(s)
Lence T., Soller M., Roignant J.Y.
ISSN
1555-8584 (Electronic)
ISSN-L
1547-6286
Statut éditorial
Publié
Date de publication
02/09/2017
Peer-reviewed
Oui
Volume
14
Numéro
9
Pages
1232-1240
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N <sup>6</sup> -methyladenosine (m <sup>6</sup> A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m <sup>6</sup> A in mRNA is dynamically regulated. A conserved methyltransferase complex catalyzes the deposition of the methyl group on adenosine, which can be removed by specific classes of demethylases. Furthermore, YTH-domain containing proteins can recognize this modification to mediate m <sup>6</sup> A-dependent activities. Here we review the functions and mechanisms of the main m <sup>6</sup> A players with a particular focus on Drosophila melanogaster.
Mots-clé
Adenosine/analogs & derivatives, Adenosine Triphosphatases/chemistry, Adenosine Triphosphatases/metabolism, Animals, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Gene Expression Regulation, Methylation, RNA Splicing, RNA, Messenger/genetics, RNA, Messenger/metabolism, Drosophila, RNA modifications, Sex lethal, m6A, neurogenesis, splicing
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/10/2019 12:52
Dernière modification de la notice
29/10/2019 6:26
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