Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
We report the case of a 75-year-old woman with a 15-year history of inappetance resulting in weight loss of approximately 40 kg. On physical examination, the skin of the lower extremities was markedly hyperpigmented with a brown-greyish hue. In addition, the skin of the legs was infiltrated, erythematous, riddled with erosions and necrotic ulcers. Clinical and laboratory evaluation revealed sicca syndrome, a pronounced polyclonal hypergammaglobulinemia (60 g/l), high levels of antinuclear, anti-SSA and anti-SSB antibodies. Histological examination of involved skin demonstrated a leukocytoclastic vasculitis.
Adenosine Triphosphatases/immunology Aged Anorexia/diagnosis/*pathology Autoantibodies/analysis Autoantigens/analysis Chronic Disease Erythema/pathology Female Humans Hypergammaglobulinemia/pathology Hyperpigmentation/pathology Leg Ulcer/*pathology Necrosis *RNA, Small Cytoplasmic Ribonucleoproteins/analysis Sjogren's Syndrome/diagnosis/*pathology Vasculitis, Hypersensitivity/pathology Weight Loss
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