Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome

Details

Serval ID
serval:BIB_930B74C0D02E
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Severe, chronic anorexia and extensive leg ulcerations as presenting signs of primary Sjogren's syndrome
Journal
Dermatology
Author(s)
Guggisberg  D., Perrenoud  D., Frenk  E.
ISSN
1018-8665
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
195
Number
1
Pages
93-5
Notes
Case Reports
Journal Article
Abstract
We report the case of a 75-year-old woman with a 15-year history of inappetance resulting in weight loss of approximately 40 kg. On physical examination, the skin of the lower extremities was markedly hyperpigmented with a brown-greyish hue. In addition, the skin of the legs was infiltrated, erythematous, riddled with erosions and necrotic ulcers. Clinical and laboratory evaluation revealed sicca syndrome, a pronounced polyclonal hypergammaglobulinemia (60 g/l), high levels of antinuclear, anti-SSA and anti-SSB antibodies. Histological examination of involved skin demonstrated a leukocytoclastic vasculitis.
Keywords
Adenosine Triphosphatases/immunology Aged Anorexia/diagnosis/*pathology Autoantibodies/analysis Autoantigens/analysis Chronic Disease Erythema/pathology Female Humans Hypergammaglobulinemia/pathology Hyperpigmentation/pathology Leg Ulcer/*pathology Necrosis *RNA, Small Cytoplasmic Ribonucleoproteins/analysis Sjogren's Syndrome/diagnosis/*pathology Vasculitis, Hypersensitivity/pathology Weight Loss
Pubmed
Web of science
Create date
15/02/2008 13:07
Last modification date
20/08/2019 14:55
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