Plasma vasopressin in rats: effect of sodium, angiotensin, and catecholamines

Détails

ID Serval
serval:BIB_92E3EBC09402
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plasma vasopressin in rats: effect of sodium, angiotensin, and catecholamines
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Brunner  D. B., Burnier  M., Brunner  H. R.
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
02/1983
Volume
244
Numéro
2
Pages
H259-65
Notes
Comparative Study Journal Article Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
A radioimmunoassay was set up to measure plasma arginine vasopressin levels (AVP). Characteristics of the assay include a sensitivity to 0.25 pg, high specificity of the antibody, mean recovery of added unlabeled arginine vasopressin of 80%, and an interassay coefficient of variation of 7.6%. This assay was used to investigate the influence of various factors on plasma vasopressin levels in a total of 121 awake male rats. Blood samples obtained in Wistar rats via an indwelling arterial catheter yielded results similar to those following decapitation, i.e., 1.27 +/- 0.26 vs. 1.68 +/- 0.39 pg/ml. Forty-eight hour dehydration markedly increased plasma AVP to 21.8 +/- 2.39 pg/ml. AVP was less than 0.5 pg/ml in Brattleboro rats. Low and high sodium intake, angiotensin II infusion (10 and 30 ng/min), and converting enzyme inhibition by captopril (100 mg/kg) did not alter plasma AVP. During norepinephrine infusion (250 ng/min) plasma AVP rose to 5.28 +/- 1.29 pg/ml, whereas it tended to fall with isoproterenol infusion (10 ng/min). Plasma AVP was slightly higher in spontaneously hypertensive rats than in Wistar-Kyoto controls.
Mots-clé
Angiotensin II/*pharmacology Animals Arginine Vasopressin/*blood Captopril/pharmacology Hypertension/physiopathology Isoproterenol/pharmacology Male Norepinephrine/*pharmacology Radioimmunoassay Rats Rats, Inbred Strains Sodium/*pharmacology Species Specificity
Pubmed
Web of science
Création de la notice
25/01/2008 13:55
Dernière modification de la notice
03/03/2018 19:33
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