From current immunosuppressive strategies to clinical tolerance of allografts.

Détails

ID Serval
serval:BIB_922E48F4882B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
From current immunosuppressive strategies to clinical tolerance of allografts.
Périodique
Transplant International
Auteur(s)
Golshayan D., Buhler L., Lechler R.I., Pascual M.
ISSN
0934-0874
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
20
Numéro
1
Pages
12-24
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Résumé
In order to prevent allograft rejection, most current immunosuppressive drugs nonspecifically target T-cell activation, clonal expansion or differentiation into effector cells. Experimental models have shown that it is possible to exploit the central and peripheral mechanisms that normally maintain immune homeostasis and tolerance to self-antigens, in order to induce tolerance to alloantigens. Central tolerance results from intrathymic deletion of T cells with high avidity for thymically expressed antigens. Peripheral tolerance to nonself-molecules can be achieved by various mechanisms including deletion of activated/effector T cells, anergy induction and active regulation of effector T cells. In this article, we briefly discuss the pathways of allorecognition and their relevance to current immunosuppressive strategies and to the induction of transplantation tolerance (through haematopoietic mixed chimerism, depleting protocols, costimulatory blockade and regulatory T cells). We then review the prospect of clinical applicability of these protocols in solid organ transplantation.
Mots-clé
Humans, Immunosuppression, Immunosuppressive Agents, Lymphocyte Activation, Models, Immunological, T-Lymphocytes, Transplantation Immunology, Transplantation, Homologous
Pubmed
Web of science
Création de la notice
29/01/2008 14:53
Dernière modification de la notice
03/03/2018 19:31
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