Microtubule gelation-contraction: essential components and relation to slow axonal transport.

Details

Serval ID
serval:BIB_9218A9073C40
Type
Article: article from journal or magazin.
Collection
Publications
Title
Microtubule gelation-contraction: essential components and relation to slow axonal transport.
Journal
Science
Author(s)
Weisenberg R.C., Flynn J., Gao B.C., Awodi S., Skee F., Goodman S.R., Riederer B.M.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Publication state
Published
Issued date
1987
Volume
238
Number
4830
Pages
1119-1122
Language
english
Abstract
Preparations of microtubule proteins isolated by assembly and disassembly undergo gelation-contraction after addition of adenosine triphosphate (ATP). A particulate fraction from these preparations that is required, along with purified tubulin, to produce ATP-dependent microtubule gelation-contraction in vitro has been isolated. The particulates exhibited microtubule-stimulated adenosine triphosphatase activity and moved slowly (about 1 micrometer per minute) along microtubule walls in the presence of ATP. The particulates contained tubulin, neurofilament, and spectrin polypeptides. The composition, solubility, and motility of the particulates are consistent with those of slow component a of axonal transport.
Keywords
Adenosine Triphosphatases/physiology, Adenosine Triphosphate/physiology, Axonal Transport, Axons/physiology, Biological Transport, Active, Gels, Microscopy, Electron, Microtubule-Associated Proteins/physiology, Microtubules/physiology, Molecular Weight
Pubmed
Web of science
Create date
24/01/2008 14:34
Last modification date
20/08/2019 14:55
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