T-cell receptor variable alpha (TCRAV) polymorphisms in European, Chinese, South American, AfroCaribbean, and Gambian populations

Détails

ID Serval
serval:BIB_91DD070A9DE8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
T-cell receptor variable alpha (TCRAV) polymorphisms in European, Chinese, South American, AfroCaribbean, and Gambian populations
Périodique
Immunogenetics
Auteur(s)
Ibberson  M. R., Copier  J. P., Llop  E., Navarrete  C., Hill  A. V., Cruickshank  J. K., So  A. K.
ISSN
0093-7711 (Print)
Statut éditorial
Publié
Date de publication
1998
Volume
47
Numéro
2
Pages
124-30
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Interactions involving the T-cell receptor (TCR) and major histocompatibility complex (MHC) are fundamental to the generation of a specific immune response. The study of interpopulation differences in TCR genes may identify those genes which are subject to selection, and also provides useful information for future genetic studies in these populations. In this study we present analysis of five TCRAV polymorphisms, for V5S1, V6S1, V8S1, V17S1, and V21S1 loci in five human populations by single-strand conformational polymorphism (SSCP) analysis. Caucasian, Chinese, Gambian, AfroCaribbean, and South American Indians (Mapuches) showed marked interpopulation variation for both the silent (V5S1, V17S1, and V21S1) and coding (V6S1 and V8S1) polymorphisms. In general the alleles were conserved in the different populations, but new, additional variants were found for V5S1 and V17S1 in Gambians and Caucasians. V6S1 overall showed the highest nucleotide diversity, and V6S1 genotype distributions were skewed away from expected values in Chinese and Mapuches. Analysis of allelic associations showed a general lack of linkage disequilibrium between the loci, which was reflected by the absence of strong population-specific haplotypes.
Mots-clé
Adult Africa Alleles Base Sequence Caribbean Region China Continental Population Groups/genetics DNA/genetics Ethnic Groups/*genetics Europe Female Gambia Gene Frequency Humans Linkage Disequilibrium Male Molecular Sequence Data *Polymorphism, Single-Stranded Conformational Receptors, Antigen, T-Cell, alpha-beta/*genetics South America
Pubmed
Web of science
Création de la notice
25/01/2008 9:39
Dernière modification de la notice
03/03/2018 19:29
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