Interrelations of immunological parameters, nutrition, and healthcare-associated infections: prospective study in elderly in-patients.

Détails

ID Serval
serval:BIB_91162C7B3455
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interrelations of immunological parameters, nutrition, and healthcare-associated infections: prospective study in elderly in-patients.
Périodique
Clinical Nutrition
Auteur(s)
Laurent M., Bastuji-Garin S., Plonquet A., Bories P.N., Le Thuaut A., Audureau E., Lang P.O., Nakib S., Liuu E., Canoui-Poitrine F., Paillaud E.
ISSN
1532-1983 (Electronic)
ISSN-L
0261-5614
Statut éditorial
Publié
Date de publication
01/2015
Peer-reviewed
Oui
Volume
34
Numéro
1
Pages
79-85
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND & AIMS: Healthcare-associated infections [HAI] are common in elderly individuals and may be related to both nutritional deficiencies and immunosenescence. Here, we assessed whether overall malnutrition and/or specific nutrient deficiencies were associated with HAI via alterations in immune parameters.
METHODS: Prospective observational cohort study in patients aged ≥ 70 years admitted to the geriatric rehabilitation unit of a teaching hospital in France between July 2006 and November 2008. Clinical and laboratory parameters reflecting nutritional status and immune function were collected at baseline. Flow cytometry was used to assess blood lymphocyte subsets including the naive CD4 T-cell count, naive and memory CD8 T-cell counts, effector CD8 T-cell count, and CD4/CD8 ratio. Patients were monitored for HAI for 3 months or until discharge from the geriatric unit or death.
RESULTS: Of 252 consecutive in-patients aged ≥ 70 years [mean age, 85 ± 6.2 years], 181 [72%] met French National Authority for Health criteria for malnutrition and 97 [38%] experienced one or more HAI. Patients who subsequently experienced HAI had significantly lower baseline values for energy intake [odds ratio (OR), 0.76; 95% confidence interval (95%CI), 0.59-0.99], serum albumin [OR, 0.43; 95%CI, 0.32-0.58], serum zinc [OR, 0.77; 95%CI, 0.62-0.97], selenium [OR, 0.76; 95%CI, 0.61-0.95], and vitamin C [OR, 0.71; 95%CI, 0.54-0.93]. Associations linking these five variables to HAI were not significantly changed by adjusting for flow cytometry T-cell subset values.
CONCLUSION: Our results suggest a direct effect of nutritional parameters on HAI rather than an indirect effect mediated by immune parameters.
Pubmed
Web of science
Création de la notice
15/04/2015 9:09
Dernière modification de la notice
03/03/2018 19:27
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