Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses.

Details

Serval ID
serval:BIB_911229E15CD2
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses.
Journal
Medicina Oral, Patología Oral Y Cirugía Bucal
Author(s)
Madrid Carlos, Aziza Jacqueline, Hlali Anasse, Bouferrache Kahina, Abarca Marcelo
ISSN
1698-6946[electronic], 1698-4447[linking]
Publication state
Published
Issued date
2010
Volume
15
Number
5
Pages
e739-e742
Language
english
Abstract
The case of a 2-month-old healthy infant without relevant medical history. The patient was referred due to the aggravation of a swelling occupying the left half of the anterior maxilla. This lesion became visible approximately one month ago; it involved the buccal gingiva and alveolar bone, including the deciduous tooth germs 6.1 and 6.2. The swelling had dimensions of 20 mm x 20 mm. The surgical excision was performed under general anesthesia. The tooth buds of 6.1 and 6.2 were closely related to the tumour and so were removed. The lesion was entirely enucleated. The pathology of the lesion confirmed a melanotic neuroectodermal tumour of infancy. The melanotic neuroectodermal tumour of infancy (MNTI) has been described as a rare benign pigmented painless swelling that usually occurs in the anterior region of the maxilla and in the incisor region. The histological examination showed small basophilic cells, many containing melanin pigmentation within the cytoplasm, with a second population of larger cubical cells with abundant cytoplasm, arranged in alveolar or adenoid clusters. According to Krompecher this tumour derives from epithelial nests evolved at the time of embryonic fusion of the facial processes. It has also been suggested that the tumour arises from the retinal anlage by a pinching-off process of neuroepithelium during the formation of embryonic eye. More recently, the presence of high levels of vanillylmandelic acid suggest a neural origin of the tumour.
Keywords
Melanotic neuroectodermal tumour, melanine, maxilla, : neural crest origin, of-the-literature
Pubmed
Web of science
Open Access
Yes
Create date
13/10/2010 13:37
Last modification date
20/08/2019 14:54
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