Additives contained in drug formulations most frequently prescribed in Switzerland

Details

Serval ID
serval:BIB_90C91A917F15
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Additives contained in drug formulations most frequently prescribed in Switzerland
Journal
Annals of Allergy
Author(s)
Kolly  M., Pecoud  A., Frei  P. C.
ISSN
0003-4738 (Print)
Publication state
Published
Issued date
01/1989
Volume
62
Number
1
Pages
21-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
The presence of substances known to induce pseudoallergic reactions was investigated by means of a questionnaire to the manufacturers of 1,467 frequently administered formulations. Benzoates were found in 15% of the formulations, sorbates in 5.5%, sulfites in 3.8%, and benzalkonium in 3.0%. The occurrence of the seven artificial colours studied was as follows: indigotin 7.8, erythrosine 7.4, sunset yellow 6.6, tartrazine 4.9, quinoline yellow 2.8%, ponceau (new coccine) 2.6, and amaranth 1.7%. A significant risk of exposure to preservatives and dyes likely to induce asthma, urticaria, or other pseudoallergic reactions exists for all individuals taking commercial drug products.
Keywords
Benzoates *Chemistry, Pharmaceutical Coloring Agents *Pharmaceutical Preparations Preservatives, Pharmaceutical Sorbic Acid Sulfites Switzerland Tartrazine
Pubmed
Web of science
Create date
28/01/2008 11:58
Last modification date
20/08/2019 14:54
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