Reversing T cell immunosenescence: why, who, and how.

Détails

ID Serval
serval:BIB_907C400D01E9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Reversing T cell immunosenescence: why, who, and how.
Périodique
Age (dordrecht, Netherlands)
Auteur(s)
Lang P.O., Govind S., Aspinall R.
ISSN
1574-4647 (Electronic)
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
35
Numéro
3
Pages
609-620
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Immunosenescence is the term commonly used to describe the multifaceted phenomenon encompassing all changes occurring in the immune system during aging. It contributes to render older adults more prone to develop infectious disease and main age-related diseases. While age clearly imposes drastic changes in immune physiology, older adults have heterogeneous health and immune phenotypes. This confronts scientists and researcher to develop more age-specific interventions rather than simply adopting intervention regimes used in younger people and this in order to maintain immune protection in older adults. Thus, this review provides evidences of the central role played by cell-mediated immunity in the immunosenescence process and explores the means by which senescent state of the cell-mediated immune function could be identified and predicted using biomarkers. Furthermore considerations are given to recent advances made in the field of age-specific immune interventions that could contribute to maintain immune protection, to improve quality of life, and/or to promote healthy aging of the growing part of the population.
Mots-clé
Aging/immunology, Humans, Immunity, Cellular/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
15/04/2015 10:15
Dernière modification de la notice
03/03/2018 19:25
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