Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine model.

Détails

ID Serval
serval:BIB_903E93920B40
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine model.
Périodique
Journal of Neuroscience
Auteur(s)
Tafti M., Nishino S., Aldrich M.S., Liao W., Dement W.C., Mignot E.
ISSN
0270-6474[print], 0270-6474[linking]
Statut éditorial
Publié
Date de publication
08/1996
Volume
16
Numéro
15
Pages
4588-4595
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Human narcolepsy is a neurological disorder known to be closely associated with HLA-DR2 and DQB1*0602. Because most autoimmune diseases are HLA-associated, a similar mechanism has been proposed for narcolepsy. However, neither systemic nor CNS evidence of an autoimmune abnormality has ever been reported. In this study, major histocompatibility (MHC) class I and class II expression was studied in the CNS of human and canine narcoleptics using immunohistochemistry and Northern analysis. Results indicated that canine narcolepsy is associated with a significant increase of MHC class II expression by the microglia. Moreover, the highest values were found between 3 and 8 months of age, strikingly concomitant to the development of narcolepsy in the canine model. In humans, class II expression was not found significantly different between control and narcoleptic subjects. This result could be explained by the old age of the subjects (69.86 +/- 5.31 and 68.36 +/- 4.74 years in narcoleptics and controls, respectively), because class II expression is significantly correlated with age in both humans and dogs. For the first time, this study demonstrated that the expression of MHC class II molecules in the CNS is age-dependent and that a consistent increase of their expression by the microglia might be critically involved in the development of narcolepsy.
Mots-clé
Aged, Animals, Central Nervous System/metabolism, Disease Models, Animal, Dogs, Female, Histocompatibility Antigens Class II/metabolism, Humans, Immunohistochemistry, Male, Microglia/metabolism, Narcolepsy/metabolism, RNA, Messenger/analysis
Pubmed
Web of science
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
03/03/2018 19:24
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