Defective death receptor signaling as a cause of tumor immune escape

Details

Serval ID
serval:BIB_901A10088FAE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Defective death receptor signaling as a cause of tumor immune escape
Journal
Seminars in Cancer Biology
Author(s)
French  L. E., Tschopp  J.
ISSN
1044-579X (Print)
Publication state
Published
Issued date
02/2002
Volume
12
Number
1
Pages
51-5
Notes
Journal Article
Review --- Old month value: Feb
Abstract
Death receptors are a subgroup of TNF-receptor family members that can trigger caspase-8 activation and apoptosis upon interaction with their selective ligands. One of the death receptors, Fas (CD95) and its ligand is critically involved in the regulation of immune homeostasis and effectorfunction. Fas-mediated cell death is a major pathway of cytolytic T-cell-mediated death that is involved in specific killing of tumor cells. Recent investigations summarized herein have shown that defective Fas-signaling due to receptor downregulation or dysfunction, or intracellular inhibition by FLIP (FLICE inhibitory protein) can interfere with Fas-mediated tumor cell death, and thereby favor tumor immune escape.
Keywords
Antigens, CD95/genetics/metabolism Humans Mutation Neoplasms/*immunology Receptors, Tumor Necrosis Factor/*metabolism *Signal Transduction
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 14:53
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