Weight cycling per se, independently of excess weight gain, promotes fat accumulation and insulin resistance

Détails

ID Serval
serval:BIB_8F6B686F006A
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Weight cycling per se, independently of excess weight gain, promotes fat accumulation and insulin resistance
Titre de la conférence
International Journal of Obesity
Auteur(s)
Prevot A, Dulloo A, Montani JP
Organisation
3rd Fribourg Obesity Research Conference (FORC-2005)
Adresse
Fribourg, SWITZERLAND, SEP 30, 2005
ISBN
0307-0565
Statut éditorial
Publié
Date de publication
12/2006
Volume
30
Pages
S69
Langue
anglais
Résumé
Many obese adults and adolescents undergo repeated cycles of dietinduced weight loss and gain, a phenomenon known as weight cycling (WC). Epidemiological studies suggest an implication of WC in increased cardiovascular morbidity/mortality. The aim of our study was to establish a rat model of WC to further evaluate its consequences on metabolic and cardiovascular diseases. Experiments were performed in male Sprague Dawley rats, initially fed with normal chow (NC 4.5% fat) for 24 days (d). Time control group I received a fixed amount of 21 g/d. Group II received the same total amount given as cycles of 3 d at -33% (14 g/d) and 3 d at +33% (28 g/d) for a total of 4 cycles. Thereafter, following a 4-d stabilization period at 21 g/d of NC, animals were switched for 14 additional days to 20 g/d of a high fat diet (23.6% fat), an amount isocaloric to 28 g of NC. At the end, a glucose tolerance test (GTT) was performed with determination of plasma glucose and insulin. Visceral fat (retroperitoneal and epididymal) was weighed and total body composition was assessed by the Soxhlet method. Despite similar body weight gain (165.8 ± 3.8 vs. 173.3 ± 2.7 g) in both groups, total body fat and visceral fat were significantly increased in cycling rats (55.6 ± 2.2 vs. 48.6 ± 1.3 g; 16.9 ± 0.8 vs. 13.9 ± 0.5 g). Cycling rats also showed a higher 30-min insulinemic response during the GTT (insulin change from baseline 6.1 ± 1.0 vs. 4.3 ± 0.9 ng/mL). Our data suggest that WC, independently of excess food intake and weight gain, may predispose to the development of cardiovascular diseases by promoting total fat and visceral fat accumulation, as well as insulin resistance.
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Création de la notice
20/07/2009 14:52
Dernière modification de la notice
03/03/2018 19:21
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