Sex-specific effects of interventions that extend fly life span.

Détails

ID Serval
serval:BIB_8F6257A5AA09
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sex-specific effects of interventions that extend fly life span.
Périodique
Science of Aging Knowledge Environment
Auteur(s)
Burger J.M., Promislow D.E.
ISSN
1539-6150[electronic]
Statut éditorial
Publié
Date de publication
2004
Volume
2004
Numéro
28
Pages
pe30
Langue
anglais
Résumé
Genetic and environmental interventions that extend life span are a current focus in research on the biology of aging. Most of this work has focused on differences among genotypes and species. A recent study on fruit flies shows that life span extension because of dietary restriction can be highly sex-specific. Here we review the literature on sex-specific effects of 56 genetic and 41 environmental interventions that extend life span in Drosophila melanogaster. We found that only one-sixth of the experiments provided statistical tests of differences in response between males and females, suggesting that sex-specific effects have been largely ignored. When measured, the life span extension was female-biased in 8 of 16 cases, male-biased in 5 of 16 cases, and not significantly different in only 3 of 16 cases. We discuss possible explanations for the sex-specific differences and suggest various ways in which we might test these hypotheses. We argue that understanding sex differences in the response to life span-extending manipulations should lead to new insights about the basic mechanisms that underlie the biology of aging in both sexes.
Mots-clé
Animals, Drosophila melanogaster/genetics, Drosophila melanogaster/physiology, Female, Longevity/genetics, Longevity/physiology, Male, Sex Factors
Pubmed
Création de la notice
19/11/2007 11:39
Dernière modification de la notice
03/03/2018 19:21
Données d'usage