Article: article from journal or magazin.
Consultation Lausannoise du retinoblastome, 1986-1990: deletions au locus de l'esterase D dans un collectif de 128 patients. [Lausanne study of retinoblastoma, 1986-90: deletion of esterase D locus in a collective of 128 patients]
Klinische Monatsblatter fur Augenheilkunde
English Abstract Journal Article --- Old month value: May
Activity and phenotype of red blood cell esterase D were systematically determined in a population of 128 retinoblastoma patients from 99 families and compared to 158 controls, in order to detect a chromosome 13q14 deletion. Among these patients 12 were healthy carriers and 116 affected carriers of a mutant allele of the retinoblastoma susceptibility gene (110 retinoblastoma, 5 retinoma, 1 phtisis bulbi). 4 patients were found to have decreased ESD levels in connection with 13q14 deletion which was confirmed by chromosome analysis. The data presented here suggest that ESD quantification has a high specificity and sensitivity for the detection of homogenous chromosome 13 deletions in retinoblastoma patients.
*Carboxylesterase Carboxylic Ester Hydrolases/*genetics *Chromosome Deletion *Chromosomes, Human, Pair 13 Eye Neoplasms/diagnosis/*genetics Female Gene Frequency/genetics Genetic Screening *Heterozygote Detection Humans Male Phenotype Retinoblastoma/diagnosis/*genetics Switzerland
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