Torasemide is an effective diuretic in the newborn rabbit.

Détails

ID Serval
serval:BIB_8F3E0AECC3B5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Torasemide is an effective diuretic in the newborn rabbit.
Périodique
Pediatric Nephrology
Auteur(s)
Dubourg L., Mosig D., Drukker A., Guignard J.P.
ISSN
0931-041X
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
14
Numéro
6
Pages
476-479
Langue
anglais
Résumé
The effect of intravenous (i.v.) torasemide on diuresis and renal function was evaluated in three groups of normoxemic, 5- to 10-day-old, newborn New Zealand White rabbits. The animals of group 1 received 0.2 mg/kg of torasemide i.v., whereas in group 2 an i.v. dose of 1.0 mg/kg was given. The third group of animals received a bolus i.v. dose of 1.0 mg/kg torasemide with continuous i.v. replacement of estimated urinary fluid and electrolyte losses. Torasemide proved to be an effective, potassium-sparing diuretic, without significant effect on glomerular filtration rate (GFR). Renal blood flow (RBF) fell and the renal vascular resistance (RVR) rose in all three groups of animals, although the rise in RVR in group 3 was not significant. These changes in renal hemodynamics were most pronounced in the animals of group 2 and are probably secondary to torasemide-induced hypovolemia (2.8% loss of body weight) and accompanying humoral reactions, such as an increase in angiotensin II (not measured). When the latter is prevented by simultaneous re-infusion of an electrolyte solution (group 3), replacing urinary losses, GFR increases and the changes in RBF and RVR are blunted. We conclude that torasemide is an effective, potassium-sparing diuretic in newborn rabbits. No evidence was found for a vasodilatory action of the drug.
Mots-clé
Animals, Animals, Newborn/physiology, Diuresis/drug effects, Diuretics/pharmacology, Glomerular Filtration Rate/drug effects, Kidney/drug effects, Kidney Function Tests, Natriuresis/drug effects, Rabbits, Renal Circulation/drug effects, Sulfonamides/pharmacology, Urodynamics/drug effects
Pubmed
Web of science
Création de la notice
17/07/2009 17:19
Dernière modification de la notice
03/03/2018 19:21
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