Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines.

Détails

ID Serval
serval:BIB_8F053033C93E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines.
Périodique
The Journal of infection
Auteur(s)
Mikulska M., Averbuch D., Tissot F., Cordonnier C., Akova M., Calandra T., Ceppi M., Bruzzi P., Viscoli C.
Collaborateur(s)
European Conference on Infections in Leukemia (ECIL)
Contributeur(s)
Akova M., Aljurf M., Averbuch D., Barnes R., Blennow O., Bochud P.Y., Bouza E., Bretagne S., Brüggemann R., Calandra T., Carratala J., Cesaro S., Cordonnier C., Cornely O., Dalianis T., De La Camara R., Donnelly P., Drgona L., Duarte R., Einsele H., Engelhard D., Fox C., Girmenia C., Groll A., Heldal D., Larsen J.H., Herbrecht R., Hirsch H., Johnson E., Klyasova G., Koskuenvo M., Lagrou K., Lewis R.E., Ljungman P., Maertens J., Maschmeyer G., Mikulska M., Nucci M., Padoin C., Pagano L., Pagliuca A., Racil Z., Ribaud P., Rinaldo C., Puechal V.R., Roilides E., Robin C., Rovira M., Rupp M., Sanchez S., Schellongowski P., Sedlacek P., Sinko J., Slavin M., Ferreira I.S., Styczynski J., Tissot F., Viscoli C., Ward K., Witschi A.T.
ISSN
1532-2742 (Electronic)
ISSN-L
0163-4453
Statut éditorial
Publié
Date de publication
01/2018
Peer-reviewed
Oui
Volume
76
Numéro
1
Pages
20-37
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Fluoroquinolone (FQ) prophylaxis was recommended in 2005 by European Conference on Infections in Leukemia (ECIL) for patients with prolonged neutropenia. In consideration of a worldwide increase in antibiotic resistance, the issue of FQ prophylaxis during neutropenia was re-evaluated.
Literature review of randomised controlled trials (RCT) and observational studies published in years 2006-2014 was performed. Their results were analysed in meta-analysis. Meta-regression model was applied to evaluate whether the rates of FQ resistance in community and hospital settings influenced the efficacy of FQ prophylaxis. The impact of FQ prophylaxis on colonisation and infection with resistant bacteria was reviewed.
Two RCTs and 12 observational studies were identified. FQ prophylaxis did not have effect on mortality (pooled OR 1.01, 95%CI 0.73-1.41), but was associated with lower rate of bloodstream infections (BSI) (pooled OR 0.57, 95%CI 0.43-0.74) and episodes of fever during neutropenia (pooled OR 0.32, 95%CI 0.20-0.50). No effect of the background rate of FQ resistance on the efficacy of FQ prophylaxis was observed. In few studies, FQ prophylaxis resulted in an increased colonisation or infection with FQ- or multi-drug resistant strains.
The possible benefits of FQ prophylaxis on BSI rate, but not on overall mortality, should be weighed against its impact in terms of toxicity and changes in local ecology in single centres.

Mots-clé
Ciprofloxacin, Febrile neutropenia, Infection, Levofloxacin, Multidrug resistance (MDR), Neutropenic, Prevention, Quinolone
Pubmed
Web of science
Création de la notice
09/11/2017 19:22
Dernière modification de la notice
03/03/2018 19:20
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