Regards recents sur la barriere hemato-encephalique. [The blood-brain barrier: recent insights]

Détails

ID Serval
serval:BIB_8E8C04B12557
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Regards recents sur la barriere hemato-encephalique. [The blood-brain barrier: recent insights]
Périodique
Revue Médicale Suisse
Auteur(s)
Buclin  T., Biollaz  J.
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
04/2005
Volume
1
Numéro
14
Pages
959-63
Notes
English Abstract
Journal Article
Review --- Old month value: Apr 6
Résumé
The blood-brain barrier must not be regarded as a purely passive wall opposing low permeability to undesirable compounds circulating in blood. It limits the access of molecules to brain tissue by a joint interplay of cerebro-spinal fluid turnover and selective uptake and expulsion of compounds through active drug carriers. The inhibition of such transporters can increase brain penetration of substrates leading to drug interactions with neuropsychiatric manifestations; it can also be exploited to increase brain and CSF concentrations of anti-infective, anti-neoplastic or psychotropic agents. Genetic polymorphisms affecting transporters may modulate the brain exposure to drugs in selected individuals. Such observations improve our understanding of a key mechanism governing clinical neuro-psychopharmacology.
Mots-clé
Animals Blood-Brain Barrier/*physiology Humans P-Glycoprotein/physiology
Pubmed
Création de la notice
25/01/2008 11:40
Dernière modification de la notice
03/03/2018 19:18
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