Descriptive epidemiology of isolated anal anomalies: a survey of 4.6 million births in Europe.

Détails

ID Serval
serval:BIB_8E783C8DAF87
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Descriptive epidemiology of isolated anal anomalies: a survey of 4.6 million births in Europe.
Périodique
American Journal of Medical Genetics
Auteur(s)
Cuschieri A.
Collaborateur(s)
EUROCAT Working group
ISSN
0148-7299
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
103
Numéro
3
Pages
207-215
Langue
anglais
Notes
(Addor M.C. included in the EUROCAT Working group)
Résumé
The prevalence of anal anomalies among 4,618,840 births recorded in 33 EUROCAT registries between 1980 and 1994 was 4.05 per 10,000 births. Of the 1,846 recorded cases, 672 (36.4%) were isolated anal anomalies while 1,174 (63.6%) occurred together with other anomalies. Only isolated anal anomalies were analyzed in this study: 75.5% were atresias, 10.1% of which were above and 89.9% were below the level of the levator ani muscle. Fistula occurred in 53% of supralevator and 37% of infralevator atresia. Other anal anomalies were ectopic anus (3.4%), congenital anal fistula (14.7%), and persistent cloaca (0.9%). There was a predominance of males in anal atresia without fistula (male to female (M:F) ratio was 6.7 for supralevator and 2.3 for infralevator atresia), but no significant sex difference in atresias with fistula. There was a predominance of females in ectopic anus and congenital anal fistula (M:F = 0.11 and 0.36 respectively). High frequencies of fetal deaths were recorded in supralevator atresia without fistula (8.3%) and in persistent cloaca (11.1%). Mean gestational length and mean birth weights were reduced for persistent cloaca but were within normal limits for other isolated anal anomalies. Odds ratios (ORs) for mothers above 35 years were increased for supralevator atresia without fistula, supralevator atresia with fistula, and congenital anal fistula. ORs for mothers below 30 years were slightly increased for supralevator atresia without fistula and decreased for persistent cloaca. There were marked differences in prevalence and distribution of anal anomalies among the EUROCAT registries. The results indicated that there are epidemiological differences among the various types of anal anomalies which might reflect different embryological origins.
Mots-clé
Anal Canal, Anus, Imperforate, Cloaca, Europe, Female, Humans, Incidence, Male, Odds Ratio, Prevalence, Rectal Fistula, Registries, Sex Factors
Pubmed
Web of science
Création de la notice
02/04/2009 9:45
Dernière modification de la notice
03/03/2018 19:18
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