The weaker points of fish acute toxicity tests and how tests on embryos can solve some issues.

Détails

ID Serval
serval:BIB_8E675341770C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The weaker points of fish acute toxicity tests and how tests on embryos can solve some issues.
Périodique
Environmental Pollution
Auteur(s)
Wedekind C., von Siebenthal B., Gingold R.
ISSN
0269-7491 (Print)
ISSN-L
0269-7491
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
148
Numéro
2
Pages
385-389
Langue
anglais
Résumé
Fish acute toxicity tests play an important role in environmental risk assessment and hazard classification because they allow for first estimates of the relative toxicity of various chemicals in various species. However, such tests need to be carefully interpreted. Here we shortly summarize the main issues which are linked to the genetics and the condition of the test animals, the standardized test situations, the uncertainty about whether a given test species can be seen as representative to a given fish fauna, the often missing knowledge about possible interaction effects, especially with micropathogens, and statistical problems like small sample sizes and, in some cases, pseudoreplication. We suggest that multi-factorial embryo tests on ecologically relevant species solve many of these issues, and we shortly explain how such tests could be done to avoid the weaker points of fish acute toxicity tests.
Mots-clé
Animals, Embryo, Nonmammalian/drug effects, Fishes/embryology, Fishes/genetics, Guidelines as Topic, Host-Parasite Interactions, Risk Assessment/methods, Sample Size, Species Specificity, Toxicity Tests, Acute/methods
Pubmed
Web of science
Création de la notice
25/01/2008 11:43
Dernière modification de la notice
03/03/2018 19:18
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