AP-1 Transcription Factors as Regulators of Immune Responses in Cancer.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_8DD31EF7BE6F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
AP-1 Transcription Factors as Regulators of Immune Responses in Cancer.
Journal
Cancers
Author(s)
Atsaves V., Leventaki V., Rassidakis G.Z., Claret F.X.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
23/07/2019
Peer-reviewed
Oui
Volume
11
Number
7
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Immune check point blockade therapy has revolutionized the standard of cancer treatment and is credited with producing remarkable tumor remissions and increase in overall survival. This unprecedented clinical success however is feasible for a limited number of cancer patients due to resistance occurring before or during a course of immunotherapy, which is often associated with activation of oncogenic signaling pathways, co-inhibitory checkpoints upregulation or expansion of immunosuppressive regulatory T-cells (Tregs) in the tumor microenviroment (TME). Targeted therapy aiming to inactivate a signaling pathway such as the Mitogen Activated Protein Kinases (MAPKs) has recently received a lot of attention due to emerging data from preclinical studies indicating synergy with immune checkpoint blockade therapy. The dimeric transcription factor complex Activator Protein-1 (AP-1) is a group of proteins involved in a wide array of cell processes and a critical regulator of nuclear gene expression during T-cell activation. It is also one of the downstream targets of the MAPK signaling cascade. In this review, we will attempt to unravel the roles of AP-1 in the regulation of anti-tumor immune responses, with a focus on the regulation of immune checkpoints and Tregs, seeking to extract useful insights for more efficacious immunotherapy.
Keywords
AP-1, CTLA-4, PD-1, PD-L1, Tregs, immune checkpoints, immunotherapy, targeted therapy, transcription factors
Pubmed
Web of science
Open Access
Yes
Create date
06/08/2019 16:45
Last modification date
14/01/2021 9:54
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