Transcription promotes contraction of CAG repeat tracts in human cells.

Détails

ID Serval
serval:BIB_8D9C9A5D0667
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transcription promotes contraction of CAG repeat tracts in human cells.
Périodique
Nature Structural and Molecular Biology
Auteur(s)
Lin Y., Dion V., Wilson J.H.
ISSN
1545-9993 (Print)
ISSN-L
1545-9985
Statut éditorial
Publié
Date de publication
2006
Volume
13
Numéro
2
Pages
179-180
Langue
anglais
Résumé
Induced transcription through CAG repeats in human cells increases repeat contraction approximately 15-fold in both confluent and proliferating cells. Repeats are stabilized against contraction by siRNA knockdown of MSH2, MSH3 or XPA, but not by knockdown of MSH6, XPC or FEN1. These results define a pathway for CAG.CTG repeat contraction that is initiated by transcription, depends on elements of mismatch and nucleotide-excision repair and does not require DNA replication.
Mots-clé
Base Sequence, Cell Line, Tumor, Humans, RNA, Small Interfering/genetics, Sequence Deletion/genetics, Transcription, Genetic/genetics, Trinucleotide Repeats/genetics
Pubmed
Web of science
Création de la notice
12/02/2014 17:24
Dernière modification de la notice
03/03/2018 19:16
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