Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases

Détails

ID Serval
serval:BIB_8C786D9ACAA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Serum and BAL macrophage migration inhibitory factor levels in HIV infected Tanzanians with pulmonary tuberculosis or other lung diseases
Périodique
Clinical Immunology
Auteur(s)
Kibiki  G. S., van der Ven  A. J., Geurts-Moespot  A., Shao  J., Calandra  T., Sweep  F. C., Dolmans  W. M.
ISSN
1521-6616 (Print)
Statut éditorial
Publié
Date de publication
04/2007
Volume
123
Numéro
1
Pages
60-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Macrophage migration inhibitory factor (MIF) activates macrophages, promotes delayed-type hypersensitivity reaction, and regulates Th1/Th2 balance in inflammatory response. Serum MIF concentration is high in patients with pulmonary tuberculosis (PTB). Higher MIF levels are associated with high mortality. No study has addressed MIF levels and its role in PTB/HIV-co infection. We determined serum and BAL MIF levels in Tanzanian HIV-infected patients with and without PTB, and correlated the levels with 1-month outcome. We compared with serum MIF levels of HIV seronegative patients with PTB and of healthy controls. All HIV-infected patients irrespective of PTB infection had significantly higher serum MIF levels than HIV-seronegative patients with PTB, and than healthy controls. In HIV seropositive patients low serum MIF levels were associated with high 1-month mortality. In conclusion, HIV infection was associated with elevated serum MIF levels regardless of PTB. Low serum MIF levels were associated with high mortality.
Mots-clé
Bronchoalveolar Lavage Fluid/chemistry Enzyme-Linked Immunosorbent Assay Female HIV Infections/blood/*complications/*immunology Humans Lung Diseases/blood/complications/immunology Macrophage Migration-Inhibitory Factors/*analysis Male Tanzania Tuberculosis, Pulmonary/blood/*complications/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 14:28
Dernière modification de la notice
03/03/2018 19:13
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