Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease

Détails

ID Serval
serval:BIB_8C50B7F4DCF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease
Périodique
Neuroscience
Auteur(s)
Bussière Thierry, Gold Gabriel, Kövari Enikö, Giannakopoulos Panteleimon, Bouras Constantin, Perl Daniel P., Morrison John H., Hof Patrick R.
ISSN
0306-4522
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
117
Numéro
3
Pages
577-592
Langue
anglais
Notes
SAPHIRID:64305
Résumé
Alzheimer's disease (AD) is characterized neuropathologically by several features including extensive neuronal death in the cerebral cortex. In fact, while neuropathological changes restricted to the hippocampal formation are a consistent reflection of age-related memory impairment, overt dementia is present only in cases with neocortical involvement. Several quantitative studies have reported a substantial loss of neurons from these regions and a parallel increase in the number of neurofibrillary tangles (NFT). However, accurate quantitative data on the dynamics of NFT formation are lacking. In the present study, we performed a stereologic analysis of the proportions of intracellular and extracellular (ghost) NFT, and unaffected neurons in the deep part of layer III (layer IIIc) and the superficial part of layer V (layer Va) of Brodmann's prefrontal cortex area 9. Elderly cognitively unimpaired cases were compared with cases with different degrees of cognitive dysfunction. The data revealed differential rates of formation of intracellular and extracellular NFT between the two layers, and confirmed the presence of a severe disease-associated, but not age-related, neuronal loss. It was also shown that a susbtantial number of pyramidal cells may persist either unaffected or in a transitional stage of NFT formation in both neocortical layers. These results suggest that a considerable number of neurons containing an intracellular NFT exists in the neocortex until late in the course of AD. Whereas it is not possible to assess whether such transitional neurons are fully functional, these affected neurons might respond positively to therapeutic strategies aimed at protecting the cells that are prone to neurofibrillary degeneration in AD. Copyright 2003 IBRO
Pubmed
Web of science
Création de la notice
10/03/2008 12:04
Dernière modification de la notice
03/03/2018 19:13
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