Human chorionic gonadotropin: does it affect human endometrial morphology in vivo?

Details

Serval ID
serval:BIB_8BAE6139C5B1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Human chorionic gonadotropin: does it affect human endometrial morphology in vivo?
Journal
Seminars in Reproductive Medicine
Author(s)
Fanchin  R., Peltier  E., Frydman  R., de Ziegler  D.
ISSN
1526-8004
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
19
Number
1
Pages
31-5
Notes
Journal Article
Review
Abstract
Human chorionic gonadotropin (hCG) is widely used as a surrogate to luteinizing hormone (LH) to trigger ovulation in controlled ovarian hyperstimulation (COH). Yet this molecule may exert direct effects on the endometrium. These effects, not mediated by ovarian hormones, are probably a consequence of stimulation of endometrial hCG/LH receptors. Because the half-life of hCG differs markedly from that of LH, possible pharmacological effects of hCG on the endometrium could alter endometrial receptivity in COH. Arguments supporting a clinical action of gonadotropins, and hCG in particular, on the endometrium abound. Notably, evidence has been reported of decidualization of stromal cells of the human endometrium in vitro as a result of exposure to gonadotropins, including hCG. The present article discusses, from a clinical standpoint, the main basis supporting the hypothesis that hCG administration as commonly used in infertility treatments may exert direct effects in vivo on endometrial histology and partake in endometrial transformations of the luteal phase. Preliminary results suggest that endometrial effects of hCG exist in vivo and should be taken into account when assessing the endometrial effects of hormones.
Keywords
Cells, Cultured Chorionic Gonadotropin/*pharmacology Endometrium/*anatomy & histology/*drug effects Estradiol/administration & dosage Female Humans Ovulation Induction Progesterone/administration & dosage
Pubmed
Web of science
Create date
28/02/2008 11:36
Last modification date
20/08/2019 14:50
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