Achievement of VGPR to induction therapy is an important prognostic factor for longer PFS in the IFM 2005-01 trial.

Details

Serval ID
serval:BIB_8B4B5AC3FE33
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Achievement of VGPR to induction therapy is an important prognostic factor for longer PFS in the IFM 2005-01 trial.
Journal
Blood
Author(s)
Moreau P., Attal M., Pégourié B., Planche L., Hulin C., Facon T., Stoppa A.M., Fuzibet J.G., Grosbois B., Doyen C., Ketterer N., Sebban C., Kolb B., Chaleteix C., Dib M., Voillat L., Fontan J., Garderet L., Jaubert J., Mathiot C., Esseltine D., Avet-Loiseau H., Harousseau J.L.
Working group(s)
IFM 2005-01 study investigators
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Publication state
Published
Issued date
2011
Volume
117
Number
11
Pages
3041-3044
Language
english
Notes
Publication types: JOURNAL ARTICLE
Abstract
In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in patients enrolled in this study. Multivariate analysis showed that ISS stages 2 and 3 and achievement of response less than very good partial response (VGPR) both after induction therapy and after autologous stem cell transplantation were adverse prognostic factors for progression-free survival, the most important one being achievement of response less than VGPR after induction. Progression-free survival was significantly improved with bortezomib-dexamethasone induction therapy in patients with poor-risk cytogenetics and ISS stages 2 and 3 compared with vincristine-adriamycin-dexamethasone. In these 2 groups of patients, achievement of at least VGPR after induction was of major importance. This study is registered with EudraCT (https://eudract.ema.europa.eu; EUDRACT 2005-000537-38) and http://clinicaltrials.gov (NCT00200681).
Pubmed
Web of science
Open Access
Yes
Create date
18/02/2011 15:07
Last modification date
20/08/2019 14:49
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