Saponins from the Spanish saffron Crocus sativus are efficient adjuvants for protein-based vaccines.

Détails

ID Serval
serval:BIB_8B47A6B8C56F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Saponins from the Spanish saffron Crocus sativus are efficient adjuvants for protein-based vaccines.
Périodique
Vaccine
Auteur(s)
Castro-Díaz N., Salaun B., Perret R., Sierro S., Romero J.F., Fernández J.A., Rubio-Moraga A., Romero P.
ISSN
1873-2518 (Electronic)
ISSN-L
0264-410X
Statut éditorial
Publié
Date de publication
2012
Volume
30
Numéro
2
Pages
388-397
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Protein and peptide-based vaccines provide rigorously formulated antigens. However, these purified products are only weakly immunogenic by themselves and therefore require the addition of immunostimulatory components or adjuvants in the vaccine formulation. Various compounds derived from pathogens, minerals or plants, possess pro-inflammatory properties which allow them to act as adjuvants and contribute to the induction of an effective immune response. The results presented here demonstrate the adjuvant properties of novel saponins derived from the Spanish saffron Crocus sativus. In vivo immunization studies and tumor protection experiments unambiguously establish the value of saffron saponins as candidate adjuvants. These saponins were indeed able to increase both humoral and cellular immune responses to protein-based vaccines, ultimately providing a significant degree of protection against tumor challenge when administered in combination with a tumor antigen. This preclinical study provides an in depth immunological characterization of a new saponin as a vaccine adjuvant, and encourages its further development for use in vaccine formulations.
Pubmed
Web of science
Création de la notice
13/01/2012 16:40
Dernière modification de la notice
03/03/2018 19:11
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